反应详情

196 mg of 7-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)-6-methoxy-1,2,3,4tetrahydroquinoline was dissolved in 5 ml of acetonitrile. Thereafter, 1 ml of 37% formalin, 190 mg of sodium cyanoborohydride, and 0.15 ml acetic acid were added to the reaction solution, and the obtained mixture was then stirred at room temperature for 1 hour. Thereafter, the reaction solution was diluted with ethyl acetate, and then washed with a saturated sodium bicarbonate aqueous solution and a saturated sodium chloride aqueous solution. The organic layer was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate), so as to obtain 100 mg of the subject compound.

1. washwashed with a saturated sodium bicarbonate aqueous solution
2. dry with materialThe organic layer was dried over magnesium sulfate
3. concentrationconcentrated under a reduced pressure
4. customThe residue was purified by NH silica gel column chromatography (hexane-ethyl acetate)