1,4-Dioxa-8-azaspiro(4.5)decane → HCID 57682911, compound

Participants

Reaction Steps

0.72 g of (6-methoxyquinolin-5-yl)acetaldehyde and 0.75 g of 1,4-dioxa-8-azaspiro[4.5]decane were dissolved in 30 ml of methylene chloride. Then, 0.50 ml of acetic acid and 0.89 g of sodium triacetoxyborohydride were added to the reaction solution, and the obtained mixture was then stirred at room temperature overnight. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by extraction with methylene chloride. The extract was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate), so as to obtain 1.01 g of the subject compound.

Provenance & Evidence