HCID 57682805, compound → HCID 57682838, compound

HRID 494984Notes

Reaction equation

HRID 494984 reaction equation
[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][C:8]2[C:13]([O:14][CH3:15])=[CH:12][C:11]([CH2:16][OH:17])=[C:10]([N+:18]([O-:20])=[O:19])[CH:9]=2)[CH2:4][O:3]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][C:8]2[C:13]([O:14][CH3:15])=[CH:12][C:11]([CH:16]=[O:17])=[C:10]([N+:18]([O-:20])=[O:19])[CH:9]=2)[CH2:4][O:3]1

Participants

4

Reactant 1

HCID 57682805HCID 57682805, compound

Product 1

HCID 57682838HCID 57682838, compoundYield 54.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Thereafter, 253 mg of (4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-5-methoxy-2-nitrophenyl)methanol was dissolved in 10 ml of methylene chloride. Then, 2.5 g of activated manganese dioxide was added to the reaction solution, and the obtained mixture was then stirred at room temperature for 66 hours. Thereafter, the reaction solution was filtered through celite, and the filtrate was concentrated under a reduced pressure, so as to obtain 137 mg of the subject compound.

Workup

  1. filtrationThereafter, the reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-cef346a764064d3694f2bbf70c053e27
Source dataset
uspto-grants-2009_05
Patent number
US07538123B2

Reaction notes

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