7-((2,2-Dimethyl-[1,3]dioxolan-4-yl)methyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroquinolin-2-one → 1-{1-[2-(6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)ethyl]piperidin-4-yl}-1H-indole-6-carboxamide

HRID 494989Notes

Reaction equation

HRID 494989 reaction equation
CC1(C)O[CH:5]([CH2:7][C:8]2[CH:17]=[C:16]3[C:11]([CH2:12][CH2:13][C:14](=[O:19])[N:15]3[CH3:18])=[CH:10][C:9]=2[O:20][CH3:21])CO1.COC1C=C2C(=CC=1CC[N:37]1[CH2:42][CH2:41][CH:40]([N:43]3[C:51]4[C:46](=[CH:47][CH:48]=[C:49]([C:52]([NH2:54])=[O:53])[CH:50]=4)[CH:45]=[CH:44]3)[CH2:39][CH2:38]1)NC(=O)CC2>>[CH3:21][O:20][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:8]=1[CH2:7][CH2:5][N:37]1[CH2:38][CH2:39][CH:40]([N:43]3[C:51]4[C:46](=[CH:47][CH:48]=[C:49]([C:52]([NH2:54])=[O:53])[CH:50]=4)[CH:45]=[CH:44]3)[CH2:41][CH2:42]1)[N:15]([CH3:18])[C:14](=[O:19])[CH2:13][CH2:12]2

Participants

3

Reactant 2

HCID 576828007-((2,2-Dimethyl-[1,3]dioxolan-4-yl)methyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroquinolin-2-oneHCID 576828961-{1-[2-(6-Methoxy-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)ethyl]piperidin-4-yl}-1H-indole-6-carboxamide

Product 1

HCID 576827921-{1-[2-(6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)ethyl]piperidin-4-yl}-1H-indole-6-carboxamide

Procedure

The subject compound was synthesized from 7-((2,2-dimethyl-[1,3]dioxolan-4-yl)methyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroquinolin-2-one according to the method described in Example 56, (5).

Sources & evidence

ORD record
ord-0cc16b300f824402bf238a651d5c9a16
Source dataset
uspto-grants-2009_05
Patent number
US07538123B2

Reaction notes

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