1,1'-Carbonyldiimidazole → HCID 60052185, compound

Participants

Reaction Steps

80 mg of 2-ethylamino-5-methoxy-4-(3-methyl-2-butenyl)phenol was dissolved in 5 ml of tetrahydrofuran under nitrogen atmosphere. Then, 0.11 g of 1,1′-carbonyldiimidazole was added to the reaction solution, and the obtained mixture was then stirred at room temperature for 1 hour. Thereafter, the mixture was further stirred at 50° C. for 1 hour. The reaction solution was concentrated under a reduced pressure. The residue was diluted with ethyl acetate and then washed with a saturated sodium chloride aqueous solution. The organic layer was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate), so as to obtain 60 mg of the subject compound.

Provenance & Evidence