Dimethylformamide → HCID 57682775, compound

Participants

Reaction Steps

901 μl of methyl iodide was added to a mixture consisting of 1.46 g of 5-allyl-6-hydroxy-3,4-dihydronaphthalen-1(2H)-one, 1.20 g of potassium carbonate, and 15 ml of N,N-dimethylformamide. The obtained mixture was stirred at room temperature under nitrogen atmosphere overnight. Thereafter, water and ethyl acetate were added to the reaction solution, so as to separate an organic layer. The obtained organic layer was washed with water (5 times) and a saturated sodium chloride solution, and then dried over anhydrous magnesium sulfate. After removing the drying agent by filtration, the organic layer was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate), so as to obtain 1.51 g of the subject compound.

Provenance & Evidence