Water → HCID 57682874, compound

Participants

Reaction Steps

4.47 g of AD-mix-β was added to a mixture consisting of 1.09 g of 5-allyl-6-methoxy-2,2-dimethyl-3,4-dihydronaphthalen-1(2H)-one, 17 ml of tert-butanol, and 17 ml of water. The obtained mixture was stirred at room temperature overnight. Thereafter, 5.37 g of sodium sulfite was added to the reaction solution, and the obtained mixture was stirred for 35 minutes, followed by extraction with ethyl acetate. The obtained organic layer was washed with a saturated sodium chloride solution and then dried over anhydrous sodium sulfate. After removing the drying agent by filtration, the reaction solution was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol), so as to obtain 1.25 g of the subject compound.

Provenance & Evidence