HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-p-Chlorophenyl chlorothioformate → 5-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butoxy}-2,3-dihydro-indole-1-carbothioic acid O-(4-chloro-phenyl)ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-p-Chlorophenyl chlorothioformate | HCID 70306 | — |
| Reactant | 2-{[4-(2,3-Dihydro-1H-indol-5-yloxy)-butyl]-ethyl amino}-ethanol | HCID 21966581 | — |
| Product | 5-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butoxy}-2,3-dihydro-indole-1-carbothioic acid O-(4-chloro-phenyl)ester | HCID 86587012 | — |
Reaction Steps
In analogy to example 7.8, 2-{[4-(2,3-Dihydro-1H-indol-5-yloxy)-butyl]-ethyl amino}-ethanol and chloro-thioformic acid (4-chloro-phenyl)ester were converted to yield 5-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butoxy}-2,3-dihydro-indole-1-carbothioic acid O-(4-chloro-phenyl)ester as yellow viscous oil, MS: 449 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706751B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-741c9458184945d2b8647fcd05a55754 |
| Source note | uspto-grants-2004_03 |