反应详情

To a solution of 2-acetyl-2,3-dihydro-5-hydroxynaphtho[2,3-b]furan-4,9-dione (IX) (0.5 g, 1.95 mmol) in chloroform (50 mL) is added manganese dioxide manufactured by Aldrich (90% activated manganese dioxide, 10 micron, 10 g), and the resulting suspension is heated to reflux for 1 day. The suspension is cooled to room temperature, and then the mixture is filtered. The filtrate is evaporated in vacuo, and the residue is purified by silica gel column chromatography (eluent:chloroform) to give 2-acetyl-5-hydroxynaphtho[2,3-b]furan-4,9-dione (I) 0.26 g (51%).

1. temperaturethe resulting suspension is heated
2. temperatureto reflux for 1 day
3. filtrationthe mixture is filtered
4. customThe filtrate is evaporated in vacuo
5. customthe residue is purified by silica gel column chromatography (eluent:chloroform)