HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 2-Phenylisobutyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 2-Phenylisobutyric acid | HCID 13222 | — |
| Reactant | Neophyl chloride | HCID 68191 | — |
| Reactant | 3,3-Dimethyl-1-indanone | HCID 304628 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Product | 2-Phenylisobutyric acid | HCID 13222 | — |
| Product | 2,5-Dimethyl-2,5-diphenylhexane | HCID 316705 | — |
Reaction Steps
A convenient synthesis into 3,3-dimethyl indan-1-one is via the acid catalysed cyclisation of phenylisobutyric acid. The phenylisobutyric acid may be prepared by reaction of neophylchloride with magnesium followed by carbon dioxide under known conditions. Typically, one obtains phenylisobutyric acid in admixture with an unwanted coupling product 2,5-dimethyl-2,5-diphenyl hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538243B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-e9d2482638e5442e8234f0af31d5e552 |
| Source note | uspto-grants-2009_05 |