Diethyl Sulfate → HCID 10171332, compound

Participants

Reaction Steps

The protocol described for 2-Ethoxymethyl-1,1,2-trimethylindan (Example 3) was repeated with 2,3,3-Trimethylindan-1-ol (1.76 g, 10 mmol), NaH (870 mg at 55%, 20 mmol, 2 equiv.) and diethyl sulphate (3.08 g, 20 mmol, 2 equiv.). The crude product obtained was purified by column chromatography on SiO2 (hexane/MTBE 19:1) followed by a bulb-to-bulb distillation at 0.15 mbar/80° C. to obtain the product as a colourless liquid in 45% yield. Only the major 1,2-trans isomer was isolated and characterised.

Provenance & Evidence