Triethylamine → HCID 13774519, compound

Participants

Reaction Steps

To the mixture of D-alanine (20.00 g; 0.224 mol) and triethylamine (31.3 ml; 0.224 mol) in absolute methanol (100 ml), ethyl trifluoroacetate (33.4 ml; 0.280 mol) is added and stirred at room temperature to homogenise the mixture (approx. 1 day). The solution is concentrated on a rotavapor (35° C.; 16 mmHg) and then dissolved in the mixture THF/water (1:1; 140 ml). Acidic ion exchanger Dowex 50W-X8 (100 g) is added, stirred for 10 minutes, filtered and concentrated again on a rotavapor (35° C.; 16 mmHg). The residue is sublimed (80° C.; 0.05 mmHg). The pure product in the form of colourless crystals is obtained (33.50 g; 80.8%).

Provenance & Evidence