Trifluoroacetic acid → HCID 178512991, compound

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Reaction Steps

Is prepared according to the procedure for N-[2-(2-oxo-2H-1-benzopyran-4-yloxy)-ethyl]-guanidine from the trifluoroacetic acid salt of 4-(3-amino-propoxy)-1-benzopyran-2-one to afford the title compound as the trifluoroacetic acid salt after HPLC purification (40.0 mg, 35%). 1H NMR (DMSO-d6, 300 MHz) δ 7.88 (1H, dd, J=1.5, 8 Hz), 7.67 (2H, m), 7.39 (2H, m), 7.15 (3H, br s), 5.92 (1H, s ), 4.26 (2H, t, J=6 Hz), 3.32 (2H, buried under solvent peak), 2.03 (2H, m); MS (ESI, Pos.) calcd for C13H15N3O3 m/z [M+H]=262.1, found 262.1.

Provenance & Evidence