HCID 11288255, compound → HCID 86035677, compound

HRID 495138Notes

Reaction equation

HRID 495138 reaction equation
[NH2:1][CH2:2]CCOC1C2C([Cl:16])=CC=CC=2OC(=O)C=1.C(OC(=O)N[CH2:25][CH2:26][CH:27]([O:29][C:30]1[C:35]2[C:36]([Cl:40])=[CH:37][CH:38]=[CH:39][C:34]=2[O:33][C:32](=[O:41])[CH:31]=1)C)(C)(C)C>>[ClH:16].[NH2:1][CH2:2][CH2:25][CH2:26][CH2:27][O:29][C:30]1[C:35]2[C:36]([Cl:40])=[CH:37][CH:38]=[CH:39][C:34]=2[O:33][C:32](=[O:41])[CH:31]=1

Participants

3

Reactant 2

HCID 11288255HCID 11288255, compoundHCID 86596926HCID 86596926, compound

Product 1

HCID 86035677HCID 86035677, compound

Procedure

Is prepared using the procedure for 4-(3-amino-propoxy)-5-chloro-1-benzopyran-2-one from [3-(5-chloro-2-oxo-2H-1-benzopyran-4-yloxy)-butyl]-carbamic acid tert-butyl ester to afford the title compound as the hydrochloric acid salt. 1H NMR (DMSO-d6, 300 MHz) δ 7.86 (3H, br s), 7.61 (1H, t, J=8.25 Hz), 7.42 (2H, t, J=9.5, 8.75 Hz), 5.96 (1H, s), 4.23 (2H, t, J=5.75 Hz), 2.85 (2H, m), 1.83 (4H, m); MS (ESI, Pos.) calcd for C13H14ClNO3 m/z [M+H]=268.1, found 268.1.

Workup

  1. customIs prepared

Sources & evidence

ORD record
ord-0c93d2e83b434b6abe400cf3ad9e6ecc
Source dataset
uspto-grants-2009_05
Patent number
US07538233B2

Reaction notes

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