Acetic Acid → HCID 11243484, compound

Participants

Reaction Steps

6-Bromo-4-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-1-benzopyran-2-one (0.893 mmol, 0.342 g) is treated with 5 mL of 4:2:1 HOAc:THF:H2O and is heated to 45° C. for 1 hr. The solvent is removed under reduced pressure and the residue is purified by HPLC to afford the title compound (105.8 mg, 60%); 1H NMR (DMSO-d6, 300 MHz) δ 7.90 (1H, d, J=2.5 Hz), 7.82 (1H, dd, J=2.25, 8.75 Hz), 7.39 (1H, d, J=8.75 Hz), 5.96 (1H, s), 4.29 (2H, t, J=6.25 Hz), 3.61 (2H, t, J=6 Hz), 1.97 (2H, m); MS (ESI, Pos.) calcd for C12H11BrO4 m/z [M+H]=299.0, found 299.1.

Provenance & Evidence