4-(6-Chloro-2-oxo-2H-1-benzopyran-4-yl)-butyronitrile → 4-(6-Chloro-2-oxo-2H-1-benzopyran-4-yl)-pentanenitrile

HRID 495151Notes

Reaction equation

HRID 495151 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9](=[O:11])[CH:8]=[C:7]([CH2:12][CH2:13][CH2:14][C:15]#[N:16])[C:6]=2[CH:17]=1.[Br-].[C:19](CCCC[Zn+])#N>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9](=[O:11])[CH:8]=[C:7]([CH:12]([CH3:19])[CH2:13][CH2:14][C:15]#[N:16])[C:6]=2[CH:17]=1

Participants

3

Reactant 2

HCID 118174844-(6-Chloro-2-oxo-2H-1-benzopyran-4-yl)-butyronitrileHCID 178510995HCID 178510995, compound

Product 1

HCID 865969294-(6-Chloro-2-oxo-2H-1-benzopyran-4-yl)-pentanenitrile

Procedure

Is prepared via the method used for 4-(6-Chloro-2-oxo-2H-1-benzopyran-4-yl)-butyronitrile except 4-cyanobutylzinc bromide is used instead of 3-cyanopropylzinc bromide.

Workup

  1. customIs prepared via the method

Sources & evidence

ORD record
ord-e36a91bb838f4277880a66e173832312
Source dataset
uspto-grants-2009_05
Patent number
US07538233B2

Reaction notes

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