1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazine → HCID 11168397, compound

Participants

Reaction Steps

A solution of 3.6 g of 3-(4-chlorobutyl)-5-methoxycarbonylindole [obtainable by reaction of 5-methoxycarbonylindole with 4-chlorobutyryl chloride to give 3-(4-chlorobutyryl)-5-methoxy indole and subsequent reduction with diborane to give 3-(4-chlorobutyl)-5-methoxycarbonylindole] and 3.4 g of 6-piperazino-1,4-benzodioxane ("A") in 200 ml of acetonitrile is stirred at room temperature for 14 hours and worked up in the conventional manner to give 6-[4-(4-(5-methoxycarbonyl indol-3-yl)butyl)piperazino]-1,4-benzodioxane, m.p. 177-179° (dihydrochloride).

Provenance & Evidence