Water → HCID 10108979, compound

Participants

Reaction Steps

To a solution of 4-benzyl 2-tert-butyl 3-ethyl-5-methyl-1H-pyrrole-2,4-dicarboxylate (2.75 mmol) in THF (32 mL), AcOH (40 mL), and H2O (32 mL) was added CAN in one portion. The reaction was stirred at room temperature for 4 hours, then poured into water (500 mL) and extracted with CH2Cl2 (3×100 mL). The combined organic solutions were washed with saturated aqueous sodium bicarbonate (1×200 mL), dried over Na2SO4 and concentrated. Purification by flash chromatography gave a white solid. HRMS (ES) exact mass calcd for C20H23NO5 (M+H+): 358.1649. Found (M+Na+): 380.1478

Provenance & Evidence