反应详情

To a flask were added 2 g benzimidazole, 3.5 g potassium carbonate, 20 ml N,N-dimethylformamide and the mixture was stirred under nitrogen. 3.2 g Benzyl chloride were added and the mixture was heated to 50 C for 16 hrs. The reaction was quenched with 40 ml water and 7 ml 3M hydrochloric acid and cooled to 5 C. The product was filtered and washed with water. The product was recrystallized by dissolving in 10 ml 2 propanol at reflux, hot filtered and 30 ml hexane were added. After cooling to 5 C, the product was filtered, washed with hexane and dried giving 1.6 g.

1. temperaturethe mixture was heated to 50 C for 16 hrs
2. customThe reaction was quenched with 40 ml water and 7 ml 3M hydrochloric acid
3. temperaturecooled to 5 C
4. filtrationThe product was filtered
5. washwashed with water
6. customThe product was recrystallized
7. dissolutionby dissolving in 10 ml 2 propanol
8. temperatureat reflux
9. filtrationhot filtered
10. addition30 ml hexane were added
11. temperatureAfter cooling to 5 C
12. filtrationthe product was filtered
13. washwashed with hexane
14. customdried
15. customgiving 1.6 g