Ammonia → HCID 23147031, compound

Participants

Reaction Steps

In the same manner as in Example 118, 1-[4,6-bis(methoxycarbonyloxy)-2-(2-methoxyethyl)-3-(3-methylphenyl)phenyl]ethanone was obtained from Compound 122 (320 mg, 1.1 mmol) obtained in Example 122, using methyl chlorocarbonate (0.21 mL, 2.7 mmol), triethylamine (0.37 mL, 2.7 mmol) and tetrahydrofuran (10 mL); and from the resulting compound, obtained was 4-ethyl-1,5-bis(methoxycarbonyloxy)-3-(2-methoxyethyl)-2-(3-methylphenyl)benzene, using sodium borohydride (160 mg, 4.3 mmol), water (5.0 mL) and tetrahydrofuran (10 mL). Then, the resulting compound was treated with methanol solution (10 mL) of 7 mmol/L ammonia to obtain Compound 130 (70 mg, 23%).

Provenance & Evidence