Ammonia → HCID 23146987, compound

Participants

Reaction Steps

In the same manner as in Example 118, methyl 3-[5-acetyl-2,4-bis(methoxycarbonyloxy)-6-(2-methoxyethyl)phenyl]benzoate was obtained from Compound 119 (100 mg, 0.30 mmol) obtained in Example 119, using methyl chlorocarbonate (0.05 mL, 0.65 mmol), triethylamine (0.09 mL, 0.65 mmol) and tetrahydrofuran (3.0 mL); and from the resulting compound, obtained was methyl 3-[5-ethyl-2,4-bis(methoxycarbonyloxy)-6-(2-methoxyethyl)phenyl]benzoate, using sodium borohydride (45 mg, 1.2 mmol), water (2.0 mL) and tetrahydrofuran (2.0 mL). Then, the resulting compound was treated with methanol solution (5.0 mL) of 7 mmol/L ammonia to obtain Compound 131 (37 mg, 37%).

Provenance & Evidence