Ammonia → HCID 23147641, compound

Participants

Reaction Steps

In the same manner as in Example 118, 1-[4,6-bis(methoxycarbonyloxy)-2-(2-methoxyethyl)-3-(3-phenylphenyl)phenyl]ethanone was obtained from Compound 120 (65 mg, 0.18 mmol) obtained in Example 120, using methyl chlorocarbonate (0.03 mL, 0.39 mmol), triethylamine (0.06 mL, 0.43 mmol) and tetrahydrofuran (3.0 mL); and from the resulting compound, obtained was 4-ethyl-1,5-bis(methoxycarbonyloxy)-3-(2-methoxyethyl)-2-(3-phenylphenyl)benzene, using sodium borohydride (30 mg, 0.79 mmol), water (2.0 mL) and tetrahydrofuran (2.0 mL). Then, the resulting compound was treated with methanol solution (5.0 mL) of 7 mmol/L ammonia to obtain Compound 132 (33 mg, 52%).

Provenance & Evidence