Ammonia → HCID 23147219, compound

Participants

Reaction Steps

In the same manner as in Example 118, 1-{4,6-bis(methoxycarbonyloxy)-2-[2-(2-methoxyethoxy)ethyl]-3-(3-methoxyphenyl)phenyl}ethanone was obtained from Compound 137 (250 mg, 0.69 mmol) obtained in Example 137, using methyl chlorocarbonate (0.15 mL, 1.9 mmol), triethylamine (0.26 mL, 1.9 mmol) and tetrahydrofuran (5.0 mL); and from the resulting compound, obtained was 4-ethyl-1,5-bis(methoxycarbonyloxy)-3-[2-(2-methoxyethoxy)ethyl]-2-(3-methoxyphenyl)benzene, using sodium borohydride (120 mg, 3.2 mmol), water (3.0 mL) and tetrahydrofuran (5.0 mL). Then, the resulting compound was treated with methanol solution (5.0 mL) of 7 mmol/L ammonia to obtain Compound 138 (110 mg, 46%).

Provenance & Evidence