Ammonia → HCID 23146899, compound

Participants

Reaction Steps

In the same manner as in Example 118, 1-{3-(3-hydroxyphenyl)-2-[2-(2-methoxyethoxy)ethyl]-4,6-bis(methoxycarbonyloxy)phenyl]ethanone was obtained from Compound 165 (320 mg, 0.92 mmol) obtained in Example 165, using methyl chlorocarbonate (0.2 mL, 2.6 mmol), triethylamine (0.4 mL, 2.9 mmol) and tetrahydrofuran (10 mL); and from the resulting compound, obtained was 4-ethyl-2-(3-hydroxyphenyl)-3-[2-(2-methoxyethoxy)ethyl]-1,5-bis(methoxycarbonyloxy)benzene, using sodium borohydride (210 mg, 5.5 mmol), water (3.0 mL) and tetrahydrofuran (5.0 mL). Then, the resulting compound was treated with methanol solution (5.0 mL) of 7 mmol/L ammonia to obtain Compound 166 (72 mg, 24%).

Provenance & Evidence