Hydrochloric Acid → HCID 23147391, compound

Participants

Reaction Steps

(5-{2-[2-Ethyl-3,5-bis(methoxymethoxy)-6-phenylphenyl]ethyl}-1,3-oxazol-4-yl)methanol (200 mg) was dissolved in methanol (5.0 mL), and 1,4-dioxane solution (1 ml) of 4.0 mol/L hydrochloric acid was added thereto and stirred at room temperature for 3 hours. The reaction liquid was neutralized with aqueous sodium hydroxide solution (1 mol/L), and then extracted with chloroform. The organic layer was washed with aqueous saturated sodium chloride solution, then dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was purified through preparative thin-layer column chromatography (chloroform/methanol=9/1) to obtain Compound 210 (53 mg, 39%).

Provenance & Evidence