1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazine → HCID 9886830, compound

HRID 4953Notes

Reaction equation

HRID 4953 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1.[N:15]1([C:21]2[CH:30]=[CH:29][C:24]3[O:25][CH2:26][CH2:27][O:28][C:23]=3[CH:22]=2)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(#N)C>[N:6]1([CH2:5][CH2:4][CH2:3][CH2:2][N:18]2[CH2:19][CH2:20][N:15]([C:21]3[CH:30]=[CH:29][C:24]4[O:25][CH2:26][CH2:27][O:28][C:23]=4[CH:22]=3)[CH2:16][CH2:17]2)[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1

Participants

4

Reactant 2

HCID 10713381-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazineHCID 222523381-(4-Bromobutyl)benzimidazole

Product 1

HCID 9886830HCID 9886830, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Analogously to Example 1, reaction of 1-(4-bromobutyl)benzimidazole with 6-piperazino-1,4-benzodioxane ("A") in 200 ml of acetonitrile gives 6-[4-(4-(benzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane, m.p. 247-248°.

Sources & evidence

ORD record
ord-6b2ca7d2d3694acca107a925b39fe209
Source dataset
uspto-grants-1993_09
Patent number
US05242925

Reaction notes

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