Hydrochloric Acid → HCID 23147238, compound

Participants

Reaction Conditions

Reaction Steps

Compound 261 (20 mg, 0.063 mmol) obtained in Example 261 was dissolved in acetonitrile (2.0 mL), and aqueous 4 mol/L sodium hydroxide solution (2.0 mL, 4.0 mmol) was added thereto and stirred at 60° C. for 3 hours. 3 mol/L hydrochloric acid (4.0 mL) was added to the reaction solution, and extracted twice with chloroform (50 mL). The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was purified through preparative thin-layer chromatography (methanol/chloroform=1/6) to obtain Compound 262 (10 mg, 52%).

Provenance & Evidence