Hydrochloric Acid → HCID 69022700, compound

Participants

Reaction Steps

Methyl 2-[5-(N-acetylaminomethyl)furan-2-yl]-3,5-bis(methoxymethoxy)phenylacetate (45 mg, 0.15 mmol) obtained in Example 264 was dissolved in dichloromethane (1.0 mL), and acetic anhydride (0.20 mL, 2.12 mmol) and pyridine (0.20 mL, 2.5 mmol) were added thereto and stirred at room temperature for 3 hours. Methanol (5.0 mL) was added to the reaction solution, then stirred for 0.5 hours, and concentrated under reduced pressure. The resulting residue was dissolved in acetonitrile (1.0 mL), and aqueous 4 mol/L sodium hydroxide solution (1.0 mL, 4.0 mmol) was added thereto and stirred at 40° C. for 4 hours. 3 mol/L hydrochloric acid (3.0 mL) was added to the reaction solution, and concentrated under reduced pressure, and the resulting residue was purified through HP-20 (Mitsubishi Chemical Industry; water to acetonitrile/water=1/4) to obtain Compound 266 (23 mg, 23%).

Provenance & Evidence