HCID 54561798, compound → HCID 74020637, compound

Participants

Reaction Conditions

Reaction Steps

(Carbomethoxymethylene)triphenylphospholane (0.17 g, 0.51 mmol) was added to toluene (4.0 mL) solution of methyl 2-bromo-6-(5-formylfuran-2-yl)-3,5-bis(methoxymethoxy)phenylacetate (0.11 g, 0.25 mmol) obtained in the step 3 in Example 265, and stirred at 60° C. for 4 h ours. The reaction solution was cooled to room temperature, and then concentrated under reduced pressure. The resulting residue was purified through silica gel column chromatography (n-hexane to ethyl acetate/n-hexane=1/2) to obtain methyl 3-{5-[3-bromo-2-(methoxycarbonylmethyl)-4,6-bis(methoxymethoxy)phenyl]furan-2-yl}acrylate (0.12 g, 93%).

Provenance & Evidence