Sulfamic Acid → HCID 86613503, compound

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Reaction Steps

Compound 230 (79.6 mg, 0.240 mmol) obtained in Example 230 was dissolved in tetrahydrofuran (10 mL), and sodium chlorite (48.7 mg, 0.538 mmol) and sulfamic acid (102 mg, 1.05 mmol) were added thereto and stirred at room temperature for 2 hours. Aqueous saturated sodium hydrogencarbonate solution and aqueous saturated sodium thiosulfate were added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, then dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was purified through preparative thin-layer chromatography (chloroform/methanol/water=100/10/1) to obtain Compound 280 (22.7 mg, 26%).

Provenance & Evidence