Formamide → HCID 135553012, compound

HRID 495357Notes

Reaction equation

HRID 495357 reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]

Participants

3

Reactant 2

HCID 713FormamideHCID 117799312-Amino-3-bromo-5-chlorobenzoic acid

Product 1

HCID 135553012HCID 135553012, compound

Procedure

8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+

Workup

  1. temperatureat reflux overnight
  2. temperatureThe mixture was cooled
  3. customquenched with water
  4. customThe solid that formed
  5. washwas washed with acetonitrile, 6.7 g crude (65%)

Sources & evidence

ORD record
ord-a9227a6d4dc548e19e26e82e61c7cba6
Source dataset
uspto-grants-2005_09
Patent number
US06939870B2

Reaction notes

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