HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 22326840, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 22326897 | HCID 22326897 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22326840 | HCID 22326840 | — |
Reaction Steps
A mixture of 1-(2-chloroethoxy)-2-methoxy-4-nitrobenzene (Step A, 1 eq), N-methylpiperazine (3 eq) and K2CO3 (2.5 eq) in CH3CN was stirred and heated under reflux until HPLC indicated the reaction was complete. The resulting solid was filtered, rinsed well with CH2Cl2 and the filtrate and washings were combined, concentrated and purified by column chromatography giving 1-[2-(2-methoxy-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06939874B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-7751c82824fa4fd3a6a4caa84299b606 |
| Source note | uspto-grants-2005_09 |