Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Ethyl 6-methoxyquinoline-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| 반응물 | tert-Butyl methyl ether | HCID 15413 | — |
| 반응물 | 6-Methoxy-3-carboxyethyl-1,2,3,4-tetrahydroquinoline | HCID 69741381 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 6-methoxyquinoline-3-carboxylate | HCID 304668 | — |
반응 단계
To a stirred solution of 6-methoxy-3-carboxyethyl-1,2,3,4-tetrahydroquinoline (Step C, 17.6 g, 0.074 mol) in CH2Cl2 (330 mL) cooled at 5° C., was added DDQ (42.2 g, 0.186 mol) portion-wise. The reaction was stirred at RT for 2 h, then diluted with MTBE (600 mL), washed twice with 1N NaOH and twice with water. Flash chromatography in 20% EtOAc/Hexane yielded 6-methoxy-3-ethoxycarbonylquinoline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06939874B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-e7176f7d9ed047e3a2f658c6cb7e1de6 |
| 출처 메모 | uspto-grants-2005_09 |