HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2-(4-Chloro-2-methoxyphenyl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-(Bromomethyl)-4-chloro-2-methoxybenzene | HCID 22327474 | — |
| Catalyst | Trioctylmethylammonium chloride | HCID 21218 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Chloro-2-methoxyphenyl)acetonitrile | HCID 22327524 | 68% |
Reaction Steps
269 g of 4-chloro-2-methoxybenzyl bromide in 214 ml of toluene are reacted with 68.2 g of sodium cyanide in 69 ml of water and 1.8 g of Aliquat 336. 141 g of colorless oil are obtained (b.p. 107° C./0.08 mbar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06939888B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-a4ffad19ff5447bab0c95824620e8ebf |
| Source note | uspto-grants-2005_09 |