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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 495556Generated: October 25, 2026

(1,1'-Biphenyl)-4-sulphonyl chloride → Biphenyl4-sulfonic acid [4-chloro-2-(pyridine-4-carbonyl)-phenyl]-amide

https://huagongshe.com/reaction/495556

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 74192—
Reactant(2-Amino-5-chlorophenyl)-pyridin-4-yl methanoneHCID 10214538—
ProductBiphenyl4-sulfonic acid [4-chloro-2-(pyridine-4-carbonyl)-phenyl]-amideHCID 10049353—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 126 mg of biphenyl-4-sulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 7.24 (m, 1H), 7.36 (m, 2H), 7.42 (m, 5H), 7.56 (m, 3H), 7.77-7.84 (m, 3H), 8.73 (d, 2H, J=4.4 Hz), 10.01 (s, 1H). MS: m/z 449.0 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06939885B2
Source datasetuspto-grants-2005_09
ORD IDord-e0a051876bb1435596f6e2bd0972fcb4
Source noteuspto-grants-2005_09