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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 495595Generated: October 25, 2026

p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-Chloro-2-(2-methyl-pyridine-3-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide

https://huagongshe.com/reaction/495595

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Trifluoromethoxy)benzenesulphonyl chlorideHCID 523102—
Reactant(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-3-yl)-methanoneHCID 22327321—
ProductN-[4-Chloro-2-(2-methyl-pyridine-3-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamideHCID 10254153—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using (2 amino-5-chloro-phenyl)-(2-methyl-pyridin-3-yl)-methanone and 4-trifluoromethoxy-benzenesulfonyl chloride and purified by HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06939885B2
Source datasetuspto-grants-2005_09
ORD IDord-90201c134da0403984f3ed38f2a1c61d
Source noteuspto-grants-2005_09