HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 6-[4-(4-(5-Acetamidoindol-3-yl)butyl)piperazino]-1,4-benzodioxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 6-[4-(4-(5-Nitroindol-3-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797324 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[4-(4-(5-Acetamidoindol-3-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797323 | — |
Reaction Steps
A solution of 4.21 g of 6-[4-(4-(5-aminoindol-3-yl)butyl)piperazino]-1,4-benzodioxane ("C") [obtainable as in Example 5] in 35 ml of THF is treated with a solution of 0.9 g of acetyl chloride in 10 ml of THF, and the mixture is stirred at 50° for 2 hours, evaporated and worked up in the conventional manner. 6-[4-(4-(5-Acetamidoindol-3-yl)butyl)piperazino]-1,4-benzodioxane is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242925 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-38db96a21eb54cbaaeba038afad9b60c |
| Source note | uspto-grants-1993_09 |