1-Chloro-2-(diethylamine)ethane hydrochloride → 1-(2-chlorophenyl)-3-[2-(diethylamino)ethyl]-2-oxo-7-(trifluoromethyl)-2,3-dihydro-1H-benzimidazole-5-carboxamide trifluoroacetate

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Reaction Steps

1-(2-Chlorophenyl)-2-oxo-7-(trifluoromethyl)-2,3-dihydro-1H-benzimidazole-5-carbonitrile (17.6 mg) was dissolved in N,N-dimethylformamide (1.5 ml), and to the solution was added sodium hydride (2.7 mg). The mixture was stirred at room temperature for 20 minutes. A solution of 2-chlorotriethylamine hydrochloride (11.7 mg) in N,N-dimethylformamide (2 ml) and triethylamine (0.011 ml) were added, and the mixture was stirred at 60-70° C. for 1 hour. After allowing to cool, to the reaction mixture was added saturated aqueous sodium bicarbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resultant residue was dissolved in 2-methyl-2-propanol (1 ml) and heated at 50° C. To the solution was added powdered potassium hydroxide (73.1 mg), and the mixture was stirred for 1 hour. After allowing to cool, to the reaction mixture was added water, and the mixture was extracted 4 times with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resultant residue was purified by HPLC using condition 1 to give the title compound (6.2 mg, 6%).

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