Hydrochloric Acid → HCID 22327391, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-[2-(diethylamino)ethyl]-2-oxo-7-(trifluoromethyl)-1-[2-(trifluoromethyl)benzyl]-2,3-dihydro-1H-benzimidazole-5-carbonitrile (2.8 mg) in t-butanol (2 ml) was stirred with heating at 60° C. To the solution was added powdered potassium hydroxide crashed in mortar (24.3 mg), and the mixture was stirred with heating at 60° C. for 30 minutes. To the reaction mixture was added 1N hydrochloric acid, and the mixture was concentrated in vacuo. The resultant residue was purified by HPLC using condition 2 to give the title compound (4.0 mg, quantitative yield).

Provenance & Evidence