Potassium Carbonate → HCID 22327398, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-[2-(diethylamino)ethyl]-2-oxo-7-(trifluoromethyl)-2,3-dihydro-1H-benzimidazole-5-carbonitrile (12.5 mg), 4-trifluoromethylbenzyl bromide (24.9 mg) and potassium carbonate (12.9 mg) in N,N-dimethylformamide (1.5 ml) was stirred with heating at 80° C. for 1.5 hours. The reaction mixture was concentrated in vacuo. To the resultant residue was added t-butanol (3 ml), and the mixture was stirred with heating at 60° C. To the solution was added powdered potassium hydroxide crashed in mortar (47.9 mg), and the mixture was stirred with heating at 60° C. for 45 minutes. To the reaction mixture was added 1N hydrochloric acid, and the mixture was concentrated in vacuo. The resultant residue was purified by HPLC using condition 2 to give the title compound (19.6 mg, 83%).

Provenance & Evidence