Acetyl chloride → 6-[4-(4-(6-Acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

HRID 4957Notes

Reaction equation

HRID 4957 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:29]=[CH:28][C:23]5[O:24][CH2:25][CH2:26][O:27][C:22]=5[CH:21]=4)[CH2:16][CH2:15]3)[C:6]=2[CH:30]=1.[C:31](Cl)(=[O:33])[CH3:32]>>[C:31]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:29]=[CH:28][C:23]5[O:24][CH2:25][CH2:26][O:27][C:22]=5[CH:21]=4)[CH2:16][CH2:15]3)[C:6]=2[CH:30]=1)(=[O:33])[CH3:32]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 197973486-[4-(4-(6-Aminobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Product 1

HCID 197973446-[4-(4-(6-Acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Procedure

Analogously to Example 6, reaction of 6-[4-(4-(6-aminobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane ("D") with acetyl chloride gives 6-[4-(4-(6-acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.

Sources & evidence

ORD record
ord-3e5d8cbf20784de7b4cf63b277ed7053
Source dataset
uspto-grants-1993_09
Patent number
US05242925

Reaction notes

Loading…