Ammonium formate → HCID 69745281, compound

Participants

Reaction Steps

To a stirred slurry of [2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[2-(4-nitro-phenoxy)-ethyl]-carbamic acid tert-butyl ester (530 mg) and 10% palladium-on-carbon (530 mg) in MeOH (20 mL) was added ammonium formate (1.2 g). After 1.5 h, the reaction mixture was filtered through Celite® washing with methanol and concentrated in vacuo. The residue was suspended in half-saturated aqueous sodium bicarbonate, washed with ethyl acetate (3×), the combined organic phases were dried (Na2SO4) and concentrated in vacuo. The resulting oil was chromatographed on a Biotage® F40S column (40% ethyl acetate/hexanes) to afford 290 mg of the title compound (I-3d) as a colorless oil.

Provenance & Evidence