反应详情

A mixture of N-(3-{5-[3-(acetamido)prop-1-ynyl]pyridin-2-yl}prop-2-ynyl)acetamide (2-1) (10 g), 10% Pd/C (1.5 g) in methanol (200 mL) was hydrogenated under 20 psi hydrogen at room temperature for 16 hours. The catalyst was removed by filtration using Solka-floc and washed with methanol. The filtrate and washings were combined and concentrated under reduced pressure to provide 10-1 as a crystalline compound (10.1 g); m.p. 95.2-97.8° C.

1. customThe catalyst was removed by filtration
2. washwashed with methanol
3. concentrationconcentrated under reduced pressure