Acetic Acid → 2-(3-{5-[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]pyridin-2-yl}propyl)-1H-isoindole-1,3(2H)-dione

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Reaction Steps

A mixture of 2-(3-{5-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl-prop-1-ynyl]pyridin-2-yl}prop-2-ynyl)-1H-isoindole-1,3(2H)-dione (5-1) (200 mg), 10% Pd/C (50 wt %; 60 mg), and acetic acid (1 mL) in DMF (1 mL) was stirred at ambient temperature under 1 atmospheric pressure of hydrogen for 2 days. The catalyst was removed by filtration through Solka-floc and washed with ethanol. The filtrate and wash were combined and concentrated under reduced pressure to give 11-1 (130 mg) as colorless crystals.

Provenance & Evidence