Acetyl chloride → 6-[4-(4-(5-Acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

HRID 4958Notes

Reaction equation

HRID 4958 reaction equation
[NH2:1][C:2]1[CH:30]=[CH:29][C:5]2[N:6]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:28]=[CH:27][C:22]5[O:23][CH2:24][CH2:25][O:26][C:21]=5[CH:20]=4)[CH2:15][CH2:14]3)[CH:7]=[N:8][C:4]=2[CH:3]=1.[C:31](Cl)(=[O:33])[CH3:32]>>[C:31]([NH:1][C:2]1[CH:30]=[CH:29][C:5]2[N:6]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:28]=[CH:27][C:22]5[O:23][CH2:24][CH2:25][O:26][C:21]=5[CH:20]=4)[CH2:15][CH2:14]3)[CH:7]=[N:8][C:4]=2[CH:3]=1)(=[O:33])[CH3:32]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 197973186-[4-(4-(5-Aminobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Product 1

HCID 197973146-[4-(4-(5-Acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Procedure

Analogously to Example 7, reaction of 6-[4-(4-(5-aminobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane ("E") with acetyl chloride gives 6-[4-(4-(5-acetamidobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.

Sources & evidence

ORD record
ord-263ca3ace86944b586055c5ed6138920
Source dataset
uspto-grants-1993_09
Patent number
US05242925

Reaction notes

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