HRID49582

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID136247

3,5-Bis(trifluoromethyl)benzaldehyde

C9H4F6O

结构：CC[C@H]1C[C@@H](N)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C

HCID69623683

未命名化合物

PRODUCTS

生成物

结构：CC[C@H]1C[C@@H](NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C

HCID131723997

未命名化合物

PROCEDURE

实验过程

treating said cis-4-amino-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester first with 3,5-bis-trifluoromethyl-benzaldehyde under acidic conditions followed by a reducing agent to form cis-4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4,-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester;

WORKUP

后处理

additiontreating

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4255667a58b641f4b7711a7a1e159ac1
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06706881B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH:1]([O:4][C:5]([N:7]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:15]=2)[C@H:10]([NH2:21])[CH2:9][C@@H:8]1[CH2:22][CH3:23])=[O:6])([CH3:3])[CH3:2].[F:24][C:25]([F:39])([F:38])[C:26]1[CH:27]=[C:28]([CH:31]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:33]=1)[CH:29]=O>>[CH:1]([O:4][C:5]([N:7]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:18])([F:19])[F:20])=[CH:14][CH:15]=2)[C@H:10]([NH:21][CH2:29][C:28]2[CH:31]=[C:32]([C:34]([F:36])([F:37])[F:35])[CH:33]=[C:26]([C:25]([F:24])([F:38])[F:39])[CH:27]=2)[CH2:9][C@@H:8]1[CH2:22][CH3:23])=[O:6])([CH3:3])[CH3:2]