Morpholine → HCID 22323653, compound

HRID 495879Notes

Reaction equation

HRID 495879 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([CH:8](Br)Br)[N:5]=[C:4]([CH:11](Br)Br)[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[CH3:1][C:2]1[N:7]=[C:6]([CH:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:5]=[C:4]([CH:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 35155HCID 35155, compound

Product 1

HCID 22323653HCID 22323653, compound

Procedure

A mixture of 2-methyl-4,6-Bis-(dibromomethyl)-s-triazine (0.4 g, 0.91 mmol) and morpholine (8 mL) was stirred at room temperature for 2 days and then heated to 70-80° C. and stirred for an additional 2 hours. The precipitate was filtered and the filtrate was evaporated under reduced pressure to remove the excess morpholine. The solid residue was recrystallized from ethyl acetate giving 0.40 g (95%) of the title compound as big cubic colorless crystals.

Workup

  1. temperatureheated to 70-80° C.
  2. stirringstirred for an additional 2 hours
  3. filtrationThe precipitate was filtered
  4. customthe filtrate was evaporated under reduced pressure
  5. customto remove the excess morpholine
  6. customThe solid residue was recrystallized from ethyl acetate giving 0.40 g (95%) of the title compound as big cubic colorless crystals

Sources & evidence

ORD record
ord-8e297a9f06a643b380154037cfbfc22a
Source dataset
uspto-grants-2005_09
Patent number
US06942966B1

Reaction notes

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