Ethanethiol → HCID 20689153, compound

Participants

Reaction Steps

A solution of 1-5 (400 mg, 1.27 mmol) in dichloromethane (5 mL) was cooled to −5° C. and treated with ethanethiol (419 mg, 6.75 mmol) and aluminum chloride (815 mg, 6.11 mmol). After 30 min, the reaction was quenched with aqueous ammonium chloride solution. The solvent was removed in vacuo and the residue dissolved in 1M HCl. The aqueous layer was extracted with three portions of dichloromethane and the combined organic extracts were washed with brine and dried (Na2SO4). The solvent was removed in vacuo. Preparative centrifugal chromatography (SiO2, 4 mm, 10% EtOH; 90% CH2C2) afforded 1-6.

Provenance & Evidence