HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Boc-beta-bromoalanine benzyl ester → (2R)-3-bromo-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Boc-beta-bromoalanine benzyl ester | HCID 11772725 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2R)-3-bromo-2-{[(tert-butoxy)carbonyl]amino}propanoic acid | HCID 20828146 | 103.3% |
Reaction Steps
The N-Boc-β-bromoalanine benzyl ester (22.0 g, 61.41 mmoles) was dissolved in tetrahydrofuran (160-180 mL) and treated with 10% Pd—C (10-15% w/w). The suspension was stirred under hydrogen atmosphere overnight. The mixture was filtered and the solvents removed to afford ˜17.0 g of the Boc-β-bromoalanine free acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06943157B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-d71a78bc7c8d441787bfd223f5c85003 |
| Source note | uspto-grants-2005_09 |