Chlorosulfonic acid → HCID 135552959, compound

HRID 496004Notes

Reaction equation

HRID 496004 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:26])[N:18]=[C:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:12]2[N:11]=1)[CH3:2].[S:27]([Cl:31])(=O)(=[O:29])[OH:28].S(Cl)(Cl)(=O)=O>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:27]([Cl:31])(=[O:29])=[O:28])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:26])[N:18]=[C:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:12]2[N:11]=1)[CH3:2]

Participants

4

Reactant 3

HCID 24638Chlorosulfonic acidHCID 24648Sulfuryl chlorideHCID 135552974HCID 135552974, compound

Product 1

HCID 135552959HCID 135552959, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 300 mg (0.84 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-n-hexyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one (Example 23A) and 0.98 g (8.4 mmol) of chlorosulphuric acid. This gives 300 mg (78.7%) of sulphonyl chloride which is directly reacted further.

Sources & evidence

ORD record
ord-4aab1593e1e34d3f8fe61a5c5d178294
Source dataset
uspto-grants-2005_09
Patent number
US06943163B2

Reaction notes

Loading…